Tobroptho L Eye Drops
Tobroptho L Eye Drops
Composition: Loteprednol Etabonate 0.5% w/v + Tobramycin Sulphate 0.3% w/v
Formulation: Eye Drops
Category: Antibiotic + Corticosteroid
Packaging: 5ML
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Tobroptho L Eye Drops
Description
Therapy/Class: Antibiotic + Corticosteroid
Mechanism of Action:
Loteprednol Etabonate: A retrometabolic, ester-based ‘soft’ corticosteroid structurally designed to provide potent localized immunosuppressive and anti-inflammatory effects, followed by predictable, rapid de-esterification into inactive carboxylic acid metabolites. This mechanism dramatically mitigates the propensity for steroid-induced intraocular pressure (IOP) elevation.
Tobramycin: A water-soluble aminoglycoside that irreversibly binds to the 30S subunit of the bacterial ribosome, inducing mRNA misreading. It exhibits excellent bactericidal activity, specifically functioning as a critical clinical tool against severe Gram-negative bacilli keratitis and conjunctivitis.
Indications
Treatment of bacterial conjunctivitis caused by susceptible organisms
Superficial ocular bacterial infections as advised by the treating ophthalmologist
Note: This is an indicative Indication, please follow the doctors advise. Do not self medicate.
Dosage & Administration
Instill 1 drop into the inferior conjunctival cul-de-sac of the affected eye(s) as prescribed by the physician. Dosing frequency should be adjusted according to clinical response and severity.
Note: This is an indicative dosage, please follow the doctors advise. Do not self medicate.
References
1. Sheppard JD, et al. Loteprednol etabonate ophthalmic suspension 0.5% in the treatment of post-operative inflammation. Clin Ophthalmol. 2014;8:2101-2110.
2. Comstock TL, et al. Safety and efficacy of loteprednol etabonate in ocular surgery. J Ocul Pharmacol Ther. 2012;28(4):359-366.
1. Wilhelmus KR, et al. Tobramycin drops vs ointment in ocular infections. Am J Ophthalmol. 1987;104(3):284-288.
Warning: This information is only for the use of registered medical practitioners only.
