Floxoptho BR Eye Drops
Floxoptho BR Eye Drops
Composition: Bromfenac 0.09% w/v + Moxifloxacin 0.5% w/v
Formulation: Eye Drops
Category: Antibiotic + NSAID
Packaging: 5ML
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Floxoptho BR Eye Drops
Description
Therapy/Class: Antibiotic + NSAID
Mechanism of Action:
Bromfenac: A highly potent, topically active nonsteroidal anti-inflammatory drug (NSAID) that halts the cyclooxygenase (COX-1 and COX-2) enzymatic pathways. The addition of a bromine atom enhances ocular tissue penetration (aqueous humor and target ciliary body) to effectively block prostaglandin biosynthesis, preventing prostaglandin-mediated miosis, hyperalgesia, and blood-aqueous barrier breakdown.
Moxifloxacin: An 8-methoxy advanced generation fluoroquinolone that optimally inhibits both Topoisomerase II and Topoisomerase IV. The methoxy group at the C-8 position minimizes the selection of resistant mutants and broadens coverage against atypical, Gram-positive, and Gram-negative organisms in ocular infections.
Indications
Treatment of bacterial conjunctivitis caused by susceptible organisms
Superficial ocular bacterial infections as advised by the treating ophthalmologist
Note: This is an indicative Indication, please follow the doctors advise. Do not self medicate.
Dosage & Administration
Instill 1 drop into the inferior conjunctival cul-de-sac of the affected eye(s) as prescribed by the physician. Dosing frequency should be adjusted according to clinical response and severity.
Note: This is an indicative dosage, please follow the doctors advise. Do not self medicate.
References
1. Donnenfeld ED, et al. Bromfenac ophthalmic solution 0.09% for postoperative ocular inflammation and pain. Ophthalmology. 2007;114(9):1625-1632.
2. Waterbury LD, et al. Inhibitory effect of bromfenac on cyclooxygenase enzymes. Invest Ophthalmol Vis Sci. 2006;47(13):1447.
1. Stroman DW, et al. In vitro and in vivo efficacy of moxifloxacin and gatifloxacin against ocular pathogens. Surv Ophthalmol. 2005;50 Suppl 1:S16-24.
Warning: This information is only for the use of registered medical practitioners only.
