Therapy/Class: Antibiotic + NSAID
Mechanism of Action:
Ketorolac Tromethamine: A direct, non-selective COX inhibitor that prevents the conversion of arachidonic acid to endoperoxides. This halts the prostaglandin-mediated inflammatory cascade, significantly raising the nociceptive threshold (reducing pain) and preventing surgically induced miosis and cystoid macular edema.
Moxifloxacin: An 8-methoxy advanced generation fluoroquinolone that optimally inhibits both Topoisomerase II and Topoisomerase IV. The methoxy group at the C-8 position minimizes the selection of resistant mutants and broadens coverage against atypical, Gram-positive, and Gram-negative organisms in ocular infections.