Poloptho DX Eye Ointment
Poloptho DX Eye Ointment
Composition: Polymyxin B Sulphate 10000 Units + Chloramphenicol 1% w/w + Dexamethasone Sodium Phosphate 0.1% w/w
Formulation: Eye Ointment
Category: Antibiotic + Corticosteroid
Packaging: 5GM
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Poloptho DX Eye Ointment
Description
Therapy/Class: Antibiotic + Corticosteroid
Mechanism of Action:
Dexamethasone: A highly efficacious, long-acting synthetic glucocorticoid that rapidly permeates the corneal epithelium to suppress cellular exudation, capillary permeability, and fibroblastic proliferation. It achieves potent suppression of the immune response by inhibiting the transcription of pro-inflammatory genes.
Polymyxin B: A bactericidal cyclic lipopeptide that targets and disrupts the outer cell membrane of Gram-negative bacilli. It binds to lipopolysaccharides, severely altering membrane permeability and causing osmotic lysis.
Chloramphenicol: A highly lipophilic, bacteriostatic agent that diffuses rapidly across ocular tissues, binding reversibly to the 50S ribosomal subunit to interrupt peptidyl transferase activity and block bacterial protein synthesis.
Indications
Treatment of bacterial conjunctivitis caused by susceptible organisms
Superficial ocular bacterial infections as advised by the treating ophthalmologist
Note: This is an indicative Indication, please follow the doctors advise. Do not self medicate.
Dosage & Administration
Extrude a 1/2 inch ribbon into the inferior conjunctival cul-de-sac of the affected eye(s) as prescribed by the physician. Dosing frequency should be adjusted according to clinical response.
Note: This is an indicative dosage, please follow the doctors advise. Do not self medicate.
References
1. Notivol R, et al. Efficacy and safety of dexamethasone in ophthalmic suspensions. Am J Ophthalmol. 2004;137(4):780-781.
2. McGhee CN, et al. Locally administered ocular corticosteroids: benefits and risks. Drug Saf. 2002;25(1):33-55.
Warning: This information is only for the use of registered medical practitioners only.
