Therapy/Class: Antibiotic
Mechanism of Action:
Ofloxacin: A fluorinated carboxyquinolone exerting potent bactericidal activity by selectively inhibiting bacterial DNA gyrase (topoisomerase II) and topoisomerase IV. This action arrests DNA replication, transcription, and repair in a broad spectrum of Gram-positive and Gram-negative ocular pathogens.
Ciprofloxacin: A second-generation fluoroquinolone providing rapid, concentration-dependent bactericidal activity by interrupting DNA gyrase, highly effective for acute bacterial keratitis.